Size: 10mg

Achieve a radiant complexion while sharpening your mind with Melanotan 1. This dual-purpose peptide supports cognitive function and enhances your natural beauty for a truly holistic approach.

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Melanotan II 10 mg for In Vitro Research

Melanotan II is a synthetic analog of alpha-melanocyte-stimulating hormone (α-MSH), developed exclusively for in vitro laboratory research. It functions as an agonist at melanocortin-3 and melanocortin-4 receptors (MC3R and MC4R).¹ These receptors, activated by peptides derived from the prohormone pro-opiomelanocortin (POMC), regulate critical biological functions such as cardiovascular activity, energy balance, hunger, glucose metabolism, and sexual function.²³⁴⁵ Research also highlights its roles in cachexia, substance use behavior, pain perception, and anxiety.²³

Behavioral and Metabolic Research

In laboratory studies, MC4R knockout rats exhibited increased food intake, weight gain, and fat accumulation. Administration of Melanotan II to these models had no impact on feeding behavior, further confirming MC4R’s role in appetite regulation.⁶ Additionally, research with neonatal prairie voles demonstrated that Melanotan II influenced social behaviors. Male voles showed reduced play-fighting, while females displayed enhanced adult partner preferences.⁷

Glucose Regulation and Leptin Signaling

Melanotan II has been investigated for its potential in glucose regulation via melanocortin and leptin pathways. Studies indicate that blocking MC3/4R receptors disrupts leptin’s glucose-lowering effects, underscoring the importance of melanocortin signaling in metabolic processes.⁸⁹ However, while MC3/4R agonists supported leptin’s actions, they were insufficient to fully reverse hyperglycemia in diabetic animal models, suggesting a complementary but not standalone role in glucose regulation.¹⁰

Research Applications

Melanotan II is a valuable research compound for studies on metabolism, behavioral science, and sexual health. Its interactions with melanocortin receptors offer insights into energy balance, cardiovascular function, glucose metabolism, and other physiological processes.

Important Notice

Melanotan II is intended strictly for in vitro research purposes. It is not approved for human use, diagnostics, or therapeutic applications. Any application outside of controlled research environments is prohibited and may pose potential risks.

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References

• 1. Bahraman AG, Jamshidzadeh A, et al. α-MSH Triggers Melanogenesis Via Activation of the Aryl Hydrocarbon Receptor Pathway. Int J Toxicol. 2021;40(2):153-160.

• 2. Corander MP, Fenech M, Coll AP. Melanocortin Action and its Impact on Body Weight and Blood Pressure. Circulation. 2009;120(22):2260-8.

• 3. Tao YX. The Melanocortin-4 Receptor: Physiology and Pharmacology. Endocr Rev. 2010;31(4):506-43.

• 4. do Carmo JM, et al. Control of Metabolic and Cardiovascular Function by Leptin-Brain Melanocortin Pathway. IUBMB Life. 2013;65(8):692-8.

• 5. da Silva AA, et al. The Brain Melanocortin System and Sympathetic Control. Physiology (Bethesda). 2014;29(3):196-202.

• 6. Mul JD, et al. MC4R Deficiency Affects Body Weight Regulation and Behavior in Rats. Obesity (Silver Spring). 2012;20(3):612-21.

• 7. Barrett CE, et al. Neonatal MC Receptor Agonist Treatment Affects Play Behavior in Prairie Voles. Neuropharmacology. 2014;85:357-66.

• 8. Xu Y, et al. Central Control of Energy and Glucose Balance by the Melanocortin System. Ann N Y Acad Sci. 2011;1243:1-14.

• 9. Morton GJ, et al. Leptin and the CNS Control of Glucose Metabolism. Physiol Rev. 2011;91(2):389-411.

• 10. da Silva AA, et al. Melanocortin System Required for Leptin’s Antidiabetic Effects. Diabetes. 2009;58(8):1749-56.